USAID's HIV Response
USAID supports country-led efforts to combat the complex challenges of HIV in over 50 countries around the world.
Read our latest story of impactPrimary Text"AIDS can be prevented. Antiretroviral drugs can extend life for many years... seldom has history offered a greater opportunity to do so much for so many.” – Former President George W. Bush, 2003 State of the Union Address, announcing the creation of the U.S. President's Emergency Plan for AIDS Relief (PEPFAR)
As a key implementer of PEPFAR, USAID’s Office of HIV/AIDS provides global leadership to the Agency’s overall response to combat the HIV epidemic. USAID supports country-led efforts to combat the complex challenges of HIV in over 50 countries around the world.
USAID’s overall goal is to support and sustain the achievement of HIV epidemic control across these countries by:
- Providing global leadership in the development of programs that maximize impact;
- Supporting country-led strategies while applying USAID’s broad health and development expertise and specialized HIV/AIDS technical competencies; and,
- Using science, technology, and innovation to support cost-effective, sustainable, and appropriately integrated HIV/AIDS interventions at scale.
USAID continues to innovate and adapt to realize efficiencies and maintain high-quality client care. We employ a "whole of Agency" approach, leveraging our considerable development assets, including our work in health, education, democracy and governance, human rights, economic growth, and humanitarian assistance.
What We Do
Through our dedicated staff around the world, host country governments, the private sector, philanthropic organizations, multilateral institutions, civil society and faith-based organizations, people living with HIV, and with the strength of our programs, we are well positioned to advance human rights, address inequality, and end HIV as a public health threat by 2030.



Where We Work
USAID delivers life-saving HIV treatment and prevention services in over 50 countries and invests in strengthening countries’ health systems to reach HIV epidemic control.
Projects and Partnerships

Maximizing Options to Advance Informed Choice for HIV Prevention (MOSAIC)
MOSAIC is a five-year (2021-2026) global project to help adolescent girls and women prevent HIV by accelerating the introduction and scale-up of new and emerging biomedical prevention products.

Adolescents and Children HIV Incidence Reduction, Empowerment and Virus Elimination (ACHIEVE)
ACHIEVE is a five-year cooperative agreement that aims to reach and sustain epidemic control in pregnant and breastfeeding women, infants, children and youth through HIV prevention and mitigation, testing, and treatment services to achieve viral suppression.

Multilateral Partnerships
The USAID Office of HIV/AIDS actively engages with the Global Fund to Fight AIDS, Tuberculosis and Malaria, UNAIDS, WHO and many other multilateral partners in the fight against HIV.

Global Health Supply Chain – Procurement and Supply Management
The project focuses on the safe, reliable supply of lifesaving medicines and diagnostics for HIV/AIDS, malaria, family planning and reproductive health, maternal, newborn and child health, and other health programs.
Stories of Impact
They’re determined, resilient, and empowered - Meet three young women who are planning for their future in Windhoek, Namibia
In Namibia, adolescent girls and young women face a higher risk of HIV infection due to factors like social isolation, poverty, discrimination, orphan hood, gender-based violence, and inadequate schooling. USAID Namibia, through the DREAMS (Determined, Resilient, Empowered, AIDS-free, Mentored and Safe) program, promotes the empowerment of adolescent girls and young women to prevent the spread of HIV.

'Every generation has to step up’: Our HIV/AIDS Staff Reflect on PEPFAR’s Impact
“The first child that died in front of me suffered from AIDS,” says Ryan Phelps, a medical officer who works in USAID’s Office of HIV/AIDS. “This made me deeply sad, and livid. We all have instances that define who we are. Moments that leave marks that are no less permanent than a tattoo…or deep scar. That was when my PEPFAR story started.”

How USAID is making life-saving HIV treatment accessible to women like Purity
According to recent global estimates by the Joint United Nations Programme on HIV/AIDS (UNAIDS), AIDS is still the leading cause of death for women of reproductive age. Pregnant women living with HIV are at a greater risk of experiencing pregnancy complications compared to women who are HIV-negative and at increased risk of life-threatening infections, such as sepsis, and opportunistic infections including tuberculosis (TB), pneumonia, and meningitis.

Local Social Workers Support Communities Across Haiti
While there have been many cases throughout Johnny Myke Alabre’s career which help illustrate the invaluable contributions social workers make towards their communities, he remembers one specific case with pride.Johnny’s role of providing psychosocial support to orphans and vulnerable children (OVC) and their family members through home visits and counseling sessions eventually led to him cross paths with Emmanuel*, a teenager living with HIV. Seventeen-year-old Emmanuel was experiencing problems with discrimination and stigma at home, and as such, he found that his dreams of becoming a musician seemed further and further away.
Twenty Years of PEPFAR
USAID Commemorates 20 years of the President’s Emergency Plan for AIDS Relief
As the world's premier international development agency, USAID drives progress through and beyond our programs to confront the greatest challenges of our time, embrace new partnerships, and invest in enduring effectiveness. For over 20 years, USAID has played a critical role in the global HIV/AIDS response, and since 2003 has led the implementation of the President’s Emergency Plan for AIDS Relief (PEPFAR), which has helped over 50 countries curb their HIV epidemics.

USAID’s Unique Role in PEPFAR
Through our dedicated staff around the world, host country governments, the private sector, philanthropic organizations, multilateral institutions, civil society and faith-based organizations, people living with HIV, and with the strength of our programs, we are well positioned to advance human rights, address inequality, and end HIV as a public health threat by 2030.

Celebrating our Dedicated Staff
Advancing human rights, addressing inequalities, and ending HIV as a public health threat would not be possible without USAID’s dedicated staff. Meet some of the current and former USAID team members who have made a difference in the world through PEPFAR.

Celebrating our Dedicated Partners
Local partners are essential to maintain treatment continuity, reduce mortality, and improve quality of life – all vital to sustaining HIV impact and long-term sustainability of the response. Meet some of the partners that have worked with USAID/PEPFAR through the years.