Artisanal and small-scale gold mining (ASGM) is a threat to biodiversity across the Amazon region, causing habitat destruction, sedimentation, and mercury accumulation that harms human health and ecosystems. Partnering with Conservation X Labs, USAID will engage with diverse innovators across the region, and, with support from the private sector, will develop and implement solutions to make legal ASGM operations more environmentally responsible and socially equitable.