The West African Ebola outbreak of 2014, infected over 28,600 people in Guinea, Sierra Leone and Liberia and killed 11,300. In response, USAID led a U.S. whole-of-government effort to contain the disease and reduced the number of Ebola cases to zero. Working in partnership with the host governments and international donors, USAID implemented a robust set of recovery and development programs designed in four pillars to address the second order impacts and ensure West Africa and other nations in the region are prepared to effectively prevent, detect, and respond to future outbreaks. As Sierra Leone, Guinea and Liberia transition to a new journey of self-reliance, the U.S. government investments has led to signature innovations, recovery gains, institutionalizing the One Health platform and Global Health Security Agenda. Credit: USAID