The Government of the Russian Federation commenced widespread attacks against Ukraine on February 24, 2022, after months of gathering hundreds of thousands of military forces and heavy weaponry near its border with Ukraine.

On February 24, USAID announced the activation of a Disaster Assistance Response Team (DART) to lead the U.S. Government humanitarian response to the crisis in Ukraine, with staff in Rzeszów, Poland; Budapest, Hungary; Chișinău, Moldova; and Bratislava, Slovakia. To support the DART, USAID activated a Response Management Team (RMT) in Washington, D.C.

Since March 2014, the conflict in eastern Ukraine has caused large-scale population displacement and widespread damage to infrastructure. The heaviest fighting has occurred in the easternmost oblasts bordering Russia, particularly Donetsk and Luhansk; however, the large influx of IDPs has also affected neighboring oblasts. The Government of Ukraine estimated that the ongoing conflict had internally displaced approximately 1.4 million people as of October 2020. In addition, the UN estimates that 2.9 million conflict-affected people in eastern Ukraine will require humanitarian assistance in 2022. Currently, the UN estimates that 6.5 million people are internally displaced across Ukraine as of October 2022 and that 17.7 million people require humanitarian assistance as of November 2022.