This is the executive summary of USAID's Global Health Strategic Framework, which sets the direction of the global health sector for fiscal years 2012–2016. The Strategic Framework incorporates the principles of the Global Health Initiative, which form the foundation of our work, is set within the U.S. Agency for International Development's (USAID's) core development mission and priorities, and promotes an inclusive and integrated approach to global health across the U.S. Government for a more effective and efficient approach to sustainable global health outcomes.