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On mainland Tanzania, more than 16 percent of all outpatient visits are attributable to malaria, resulting in approximately 4.4 million clinical and confirmed malaria cases annually. With 93 percent of people on the mainland residing in malaria endemic areas, the disease remains a major contributor to maternal, newborn, and under-five mortality. The U.S. President’s Malaria Initiative (PMI) strives to reduce malaria deaths and substantially decrease malaria prevalence with the long-term goal of elimination. With support from PMI and its partners, malaria control interventions are being expanded and critical commodities are being distributed to vulnerable populations.