The Global Health Security Agenda (GHSA) was launched in 2014 as epidemics such as SARS, H1N1 influenza, MERS-CoV, H7N9 and Ebola had demonstrated an ability to spread quickly across borders in our increasingly interconnected world. GHSA works through the “One Health” approach which unites human, animal, and environmental health into a comprehensive, multi-sectoral framework. This approach recognizes that stressors in any one domain impact the others and increase the likelihood of experiencing deadly outbreaks. Mali is especially vulnerable to epidemics of potential global significance because of its proximity to countries that have recently experienced epidemics. Characteristics such as deforestation and desertification, conflict and environmentally driven displacement, poverty, a weak healthcare infrastructure, and a predominantly agricultural and pastoral workforce also put Malians at risk.