The U.S. Government has long been a leader in improving nutrition to save lives and enhance the prospects of future generations globally. The U.S. Government Global Nutrition Coordination Plan 2016–2021 was developed to amplify the government’s diverse nutrition investments through better communication and collaboration across U.S. Government agencies and departments and by linking research to program implementation. The Coordination Plan began after the historic 2013 Nutrition for Growth Summit in London, where the U.S. Government committed to developing a government-wide nutrition plan to accelerate progress toward relevant World Health Assembly targets, the Sustainable Development Goals, and other global commitments. Over three years, eight departments and independent agencies developed the Coordination Plan, including the Millennium Challenge Corporation (MCC), Peace Corps, U.S. Agency for International Development (USAID), U.S. Department of Agriculture (USDA), U.S. Department of Health and Human Services (HHS), U.S. Department of State, U.S. Department of Treasury, and the White House Office of Science and Technology Policy. By nurturing cross-government partnerships and coordination, the Coordination Plan magnifies the reach and effectiveness of U.S. Government programs and investments. This annual summary describes the progress during the third year of implementation and outlines plans for the coming year.