The USAID/Eastern and Southern Caribbean (USAID/ESC) Mission’s goal for the 2020-2025 Regional Development Cooperation Strategy (RDCS) is to support the ESC in creating “a safe, prosperous, and resilient Caribbean region that supports its vulnerable populations, withstands external shocks, and promotes accountable institutions, economic development, and private sector-led growth.” To achieve sustained transformative development, the ESC will need to address key challenges around fiscal management, governments’ capacity to be responsive to citizens, diversification of economic opportunities, security, education, and mitigation of disasters. The Results Framework developed for this RDCS positions the ESC to engage with the private sector and other key stakeholders in the region; use resilience as a guiding principle throughout the strategy; and emphasize a redefined model of USAID and government partnerships, including with regional organizations.