The purpose of the U.S. Government Global Nutrition Coordination Plan (2021–2026) is to maximize the impact of investments across the continuum of nutrition-related research, policies, programs, and other efforts to accelerate achievement of global nutrition goals and increase whole-of-government responsiveness to emerging evidence, opportunities, and threats. Through this interagency coordination platform, the U.S. government will maximize its support to country- and region-led efforts, continue its global leadership and partnerships, and generate, share, and apply knowledge and evidence in order to accelerate progress toward shared nutrition goals.